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Southampton to host trials of Cambridge-developed coronavirus vaccine

Published:?26?August?2020
Coronavirus
The Cambridge trial aims to make a vaccine to protect against SARS-CoV-2 and related coronaviruses.

A Cambridge-developed vaccine candidate against SARS-CoV-2 could begin clinical trials in the UK as early as autumn, thanks to a £1.9 million award from the UK government.

Innovate UK, the UK government’s innovation agency, has provided the funding for a collaboration between Cambridge spin-out company DIOSynVax (which is contributing an additional £400,000 to the trial), the University of Cambridge and the University Hospital Southampton NHS Foundation Trust.

The approach for this vaccine trial involves 3D computer modelling of the SARS-CoV-2 virus’s structure. It uses information on the virus itself as well as its relatives – SARS, MERS and other coronaviruses carried by animals that threaten to ‘spill-over’ to humans again to cause future human epidemics.

Professor Jonathan Heeney, head of the Laboratory of Viral Zoonotics at the University of Cambridge, and founder of DIOSynVax, said:

“We’re looking for chinks in its armour, crucial pieces of the virus that we can use to construct the vaccine to direct the immune response in the right direction. Ultimately we aim to make a vaccine that will not only protect from SARS-CoV-2, but also other related coronaviruses that may spill over from animals to humans.

“Our strategy includes targeting those domains of the virus’s structure that are absolutely critical for docking with a cell, while avoiding the parts that could make things worse,” Professor Heeney continued. “What we end up with is a mimic, a synthetic part of the virus minus those non-essential elements that could trigger a bad immune response.”

The UKRI funding will allow the team to take the vaccine candidate to clinical trial, to take place in Southampton and could begin as early as autumn this year. Southampton is already hosting the University of Oxford and Imperial Colege coronavirus vaccine trials which are currently underway in the city.

Professor Saul Faust, Professor of Paediatric Immunology and Infectious Diseases at the University of Southampton and Director of the NIHR Southampton Clinical Research Facility, said: “It is critical that different vaccine technologies are tested as part of the UK and global response to the pandemic as at this stage no one can be sure which type of vaccine will produce the best and most long-lived immune responses.

“It is especially exciting that the clinical trial will test giving the vaccine through people’s skin using a device without any needles as together with stable DNA vaccine technology this could be a major breakthrough in being able to give a future vaccine to huge numbers of people across the world.”

SARS-CoV-2 is a coronavirus, a class of virus named after their appearance: spherical objects, on the surface of which sit ‘spike’ proteins. The virus uses these spikes to attach to and invade cells in our body. One vaccine strategy is to block this attachment; however, not all immune responses against this virus and against this spike protein are protective – antibodies to the wrong part of the spike protein have been implicated in triggering hyper-inflammatory immune responses, causing life-threatening COVID-19 disease. Added to this, SARS-CoV-2 is mutating and changes in the virus spike protein during the COVID-19 pandemic have already been observed to be widespread.

To develop their new vaccine candidate – DIOS-CoVax2 – the team uses banks of genetic sequences of all known coronaviruses, including those from bats, the natural hosts of many relatives of human coronaviruses. The team has developed libraries of computer-generated antigen structures encoded by synthetic genes that can train the human immune system to target key regions of the virus and to produce beneficial anti-viral responses. These immune responses include neutralising antibodies, which block virus infection, and T-cells, which remove virus-infected cells. This ‘laser-specific’ computer generated approach is able to help avoid the adverse hyper-inflammatory immune responses that can be triggered by recognition of the wrong parts on the coronavirus’s surface.

While most vaccines use RNA or adenoviruses to deliver their antigens, DIOSynVax’s is based around DNA. These synthetic gene inserts are very versatile and can also be placed within a number of different vaccine delivery systems that other companies are using. Once an antigen is identified, the key piece of genetic code that the virus uses to produce the essential parts of its structure is inserted into a DNA parcel known as a vector. The body’s immune cells take up the vector, decode the DIOS-vaccine antigen and use the information to program the rest of the immune system to produce antibodies against it.

This DNA vector has already been shown to be safe and effective at stimulating an immune response against other pathogens in multiple phase I and early phase II trials.

The proposed vaccine can be freeze-dried as a powder and is therefore heat stable, meaning that it does not need to be cold-stored. This makes transport and storage much more straightforward – which is particularly important in low- and middle-income countries where the infrastructure to make this possible can be costly. The vaccine can be delivered pain-free without a needle into the skin, using a simple jet of air.

Dr Rebecca Kinsley, Chief Operating Officer of DIOSynVax and a postdoctoral researcher at the University of Cambridge, added: “Most research groups have used established approaches to vaccine development because of the urgent need to tackle the pandemic. We all hope the current clinical trials have a positive outcome, but even successful vaccines are likely to have their limitations – they may be unsuitable for vulnerable people, and we do not know how long their effects will last for, for example.

“Our approach – using synthetic DNA to deliver custom designed, immune selected vaccine antigens – is revolutionary and is ideal for complex viruses such as coronavirus. If successful, it will result in a vaccine that should be safe for widespread use and that can be manufactured and distributed at low cost.”

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